The appropriateness of penicillin allergy de-labelling by non-allergist clinical ward teams.
Clin Med (Lond)
; 24(4): 100225, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38944245
ABSTRACT
OBJECTIVES:
We aimed to assess the appropriateness of penicillin allergy (PenA) assessment conducted by clinical teams and to review the safety of subsequent exposure of these patients to penicillin.METHODS:
Opportunistic, prospective observational study of usual clinical care, between 16 May 2023 and 14 August 2023, of inpatients with a PenA and requiring antibiotics, in a 750-bed hospital in England. To assess the appropriateness of management, PenA patients prescribed penicillins were grouped into risk categories using a validated antibiotic allergy assessment tool eligible for de-label on history alone (direct de-label; DDL), eligible for direct oral challenge (DOC), high risk or unable to obtain history.RESULTS:
Of the 123 patients admitted with a PenA (or sensitivity record) and exposed to a penicillin, data were collected for 50. Their PenA records were grouped follows eligible for DDL 34 (68%), eligible for DOC 11 (22%), high risk 4 (8%) and unable to obtain history 1 (2%). In 14/50 (28%) patients there was no evidence of a current PenA assessment in the medical notes.CONCLUSIONS:
Using the allergy risk tool, most patients with PenA records were exposed to penicillin appropriately. However, patients meeting high-risk criteria were also exposed to penicillin when the tool excluded them. PenA assessment needs to be carried out with appropriate training and governance structures in place.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Penicilinas
/
Hipersensibilidade a Drogas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article