Monoterpene-chalcone conjugates and diarylheptanoids isolated from the seeds of Alpinia katsumadai Hayata with cytotoxic activity.
Phytochemistry
; 225: 114197, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38945281
ABSTRACT
Five undescribed monoterpene-chalcone conjugates (1-5), one undescribed hypothetical precursor of diarylheptanoid (6), two undescribed diarylheptanoids (7-8), and fourteen known compounds (9-22) were isolated from the seeds of Alpinia katsumadai. Their structures were elucidated through the interpretation of HRESIMS, NMR, ECD, and X-ray diffraction data. MTT assays on human cancer cell lines (HepG2, A549, SGC7901, and SW480) revealed that compounds 3-8, 11, and 13 exhibited broad-spectrum antiproliferative activities with IC50 values ranging from 3.59 to 21.78 µM. B cell lymphoma 2 was predicted as the target of sumadain C (11) by network pharmacology and verified by homogeneous time-resolved fluorescence assay and molecular docking.
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Base de dados:
MEDLINE
Assunto principal:
Sementes
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Ensaios de Seleção de Medicamentos Antitumorais
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Alpinia
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Diarileptanoides
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Monoterpenos
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Proliferação de Células
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Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article