Asymmetric dearomatization of benzyl 1-naphthyl ethers via [1,3] O-to-C rearrangement.
Chem Commun (Camb)
; 60(58): 7507-7510, 2024 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-38949684
ABSTRACT
A catalytic asymmetric dearomatization reaction of benzyl 1-naphthyl ethers accelerated by a chiral N,N'-dioxide/Co(II) complex is disclosed. The reaction proceeds via an enantioselective [1,3] O-to-C rearrangement through a tight ion-pair pathway, providing a wide array of α-naphthalenone derivatives bearing an all-carbon quaternary center in high yields with excellent ee values.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
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Article