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Inappropriate treatment of pulmonary aspergillosis caused by Aspergillus flavus in susceptible pediatric patients: a case series.
Hosseinikargar, Neginsadat; Zarrinfar, Hossein; Seyedi, Seyed Javad; Mojtahedi, Seyedeh Sabereh.
Afiliação
  • Hosseinikargar N; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Zarrinfar H; Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Zarrinfarh@mums.ac.ir.
  • Seyedi SJ; Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Zarrinfarh@mums.ac.ir.
  • Mojtahedi SS; Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Med Case Rep ; 18(1): 301, 2024 Jul 02.
Article em En | MEDLINE | ID: mdl-38951939
ABSTRACT

BACKGROUND:

Pulmonary aspergillosis is a prevalent opportunistic fungal infection that can lead to mortality in pediatric patients with underlying immunosuppression. Appropriate and timely treatment of pulmonary aspergillosis can play a crucial role in reducing mortality among children admitted with suspected infections. CASE PRESENTATION The present study reports three cases of inappropriate treatment of pulmonary aspergillosis caused by Aspergillus flavus in two Iranian pediatric patients under investigation and one Afghan patient. Unfortunately, two of them died. The cases involved patients aged 9, 1.5, and 3 years. They had been diagnosed with pulmonary disorders, presenting nonspecific clinical signs and radiographic images suggestive of pneumonia. The identification of A. flavus was confirmed through DNA sequencing of the calmodulin (CaM) region.

CONCLUSION:

A. flavus was the most prevalent cause of pulmonary aspergillosis in pediatric patients. Early diagnosis and accurate antifungal treatment of pulmonary aspergillosis could be crucial in reducing the mortality rate and also have significant potential for preventing other complications among children. Moreover, antifungal prophylaxis seems to be essential for enhancing survival in these patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus flavus / Aspergilose Pulmonar / Antifúngicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus flavus / Aspergilose Pulmonar / Antifúngicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article