Neutrophil extracellular traps-inspired DNA hydrogel for wound hemostatic adjuvant.
Nat Commun
; 15(1): 5557, 2024 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-38956415
ABSTRACT
Severe traumatic bleeding may lead to extremely high mortality rates, and early intervention to stop bleeding plays as a critical role in saving lives. However, rapid hemostasis in deep non-compressible trauma using a highly water-absorbent hydrogel, combined with strong tissue adhesion and bionic procoagulant mechanism, remains a challenge. In this study, a DNA hydrogel (DNAgel) network composed of natural nucleic acids with rapid water absorption, high swelling and instant tissue adhesion is reported, like a band-aid to physically stop bleeding. The excellent swelling behavior and robust mechanical performance, meanwhile, enable the DNAgel band-aid to fill the defect cavity and exert pressure on the bleeding vessels, thereby achieving compression hemostasis for deep tissue bleeding sites. The neutrophil extracellular traps (NETs)-inspired DNAgel network also acts as an artificial DNA scaffold for erythrocytes to adhere and aggregate, and activates platelets, promoting coagulation cascade in a bionic way. The DNAgel achieves lower blood loss than commercial gelatin sponge (GS) in male rat trauma models. In vivo evaluation in a full-thickness skin incision model also demonstrates the ability of DNAgel for promoting wound healing. Overall, the DNAgel band-aid with great hemostatic capacity is a promising candidate for rapid hemostasis and wound healing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
DNA
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Hemostáticos
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Hidrogéis
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Armadilhas Extracelulares
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Hemostasia
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article