Episodes of acute methotrexate-related neurotoxicity linked to compromised long-term neurocognitive function.
Pediatr Blood Cancer
; 71(9): e31169, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38961583
ABSTRACT
Methotrexate is a critical component of curative chemotherapy for pediatric acute lymphoblastic leukemia (ALL), but is associated with neurotoxicity. Information on long-term outcomes following an acute neurotoxic event is limited. Therefore, this report compares neurocognitive performance more than 12 months post diagnosis (mean = 4 years) between ALL patients with (n = 25) and without (n = 146) a history of acute neurotoxicity. Compared to children with no documented on-treatment neurotoxic event, children who experienced a neurotoxic event during treatment exhibited poorer performance on measures of fine motor function (p = .02) and attention (p = .02). Children with ALL who experience acute neurotoxicity may be candidates for early neuropsychological screening and intervention.
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Base de dados:
MEDLINE
Assunto principal:
Metotrexato
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Síndromes Neurotóxicas
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Antimetabólitos Antineoplásicos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article