[The prognostic value of colonoscopy grading for acute graft-versus-host disease in patients with malignant hematological disorders after unrelated cord blood transplantation].
Zhonghua Xue Ye Xue Za Zhi
; 45(5): 462-467, 2024 May 14.
Article
em Zh
| MEDLINE
| ID: mdl-38964920
ABSTRACT
Objective:
To investigate the prognostic value of enteroscopic grading for the prognostic assessment of patients with malignant hematological diseases who developed intestinal acute graft-versus-host disease (IT-aGVHD) after unrelated cord blood transplantation (UCBT) .Methods:
Fifty patients with IT-aGVHD who developed hormone resistance after UCBT from June 2016 to June 2023 at Anhui Provincial Hospital were collected to compare the effective and survival rates of IT-aGVHD treatment in the group with milder enteroscopic mucosal injury (27 cases, enteroscopic grading of â and â ¡) and the group with more severe injury (23 cases, enteroscopic grading of â ¢ and â £) and to retrospectively analyze the factors affecting patients' prognosis.Results:
Patients in the mild and severe groups had an effective rate of 92.6% and 47.8% at 28 days after colonoscopy (P<0.001), 81.5% and 39.1% at 56 days after colonoscopy (P=0.002), with optimal effective rate of 92.6% and 65.2% (P=0.040), respectively, and the differences were statistically significant. The multifactorial analysis found that enteroscopic grading was an independent risk factor affecting the effective rate of IT-aGVHD treatment. The overall survival rate at 2 years after colonoscopy was 70.4% (95% CI 52.0% -88.8% ) and 34.8% (95% CI 14.8% -54.8% ) for patients in the mild and severe groups, respectively, and the difference was statistically significant (P=0.003). Multifactorial analysis revealed that enteroscopic grading, cytomegalovirus infection status, second-line treatment regimen, and patients' age were independent risk factors for survival.Conclusion:
The treatment efficacy and prognosis of patients in the group with less severe enteroscopic injury (grades â and â ¡) were better than those in the group with more severe injury (grades â ¢ and â £) .Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colonoscopia
/
Transplante de Células-Tronco de Sangue do Cordão Umbilical
/
Doença Enxerto-Hospedeiro
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article