CD300LF+ microglia impede the neuroinflammation following traumatic brain injury by inhibiting STING pathway.
CNS Neurosci Ther
; 30(7): e14824, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38965803
ABSTRACT
INTRODUCTION:
The diversity in microglial phenotypes and functions following traumatic brain injury (TBI) is poorly characterized. The aim of this study was to explore precise targets for improving the prognosis of TBI patients from a microglial perspective.OBJECTIVES:
To assess whether the prognosis of TBI can be improved by modulating microglia function.RESULTS:
In CD300LF-deficient mice, we observed an increase in glial cell proliferation, more extensive neuronal loss, and worsened neurological function post-TBI. Transcriptomic comparisons between CD300LF-positive and CD300LF-negative microglia illuminated that the neuroprotective role of CD300LF is principally mediated by the inhibition of the STING signaling pathway. In addition, this protective effect can be augmented using the STING pathway inhibitor C-176.CONCLUSIONS:
Our research indicates that CD300LF reduces neuroinflammation and promotes neurological recovery after TBI, and that microglia are integral to the protective effects of CD300LF in this context. In summary, our findings highlight CD300LF as a critical molecular regulator modulating the adverse actions of microglia following acute brain injury and propose a novel therapeutic approach to enhance outcomes for patients with TBI.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
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Transdução de Sinais
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Microglia
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Lesões Encefálicas Traumáticas
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Doenças Neuroinflamatórias
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Proteínas de Membrana
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Camundongos Endogâmicos C57BL
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article