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A temperature compensated fiber probe for highly sensitive detection in virus gene biosensing.
Han, Xiaopeng; Zhang, Yu; Zhang, Yundong; Song, Qinghao; Hasi, Wuliji; Lin, Siyu; Wang, Fan.
Afiliação
  • Han X; The National Key Laboratory of Tunable Laser Technology, Institute of Opto-Electronics, Harbin Institute of Technology, Harbin, 150080, China.
  • Zhang Y; Space Environment Simulation Research Infrastructure, Harbin Institute of Technology, Harbin, 150080, China; School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.
  • Zhang Y; The National Key Laboratory of Tunable Laser Technology, Institute of Opto-Electronics, Harbin Institute of Technology, Harbin, 150080, China; College of Aeronautics and Astronautics, Harbin Institute of Technology, Harbin, 150080, China. Electronic address: ydzhang@hit.edu.cn.
  • Song Q; Space Environment Simulation Research Infrastructure, Harbin Institute of Technology, Harbin, 150080, China. Electronic address: songqinghao@hit.edu.cn.
  • Hasi W; The National Key Laboratory of Tunable Laser Technology, Institute of Opto-Electronics, Harbin Institute of Technology, Harbin, 150080, China; College of Aeronautics and Astronautics, Harbin Institute of Technology, Harbin, 150080, China.
  • Lin S; The National Key Laboratory of Tunable Laser Technology, Institute of Opto-Electronics, Harbin Institute of Technology, Harbin, 150080, China.
  • Wang F; The National Key Laboratory of Tunable Laser Technology, Institute of Opto-Electronics, Harbin Institute of Technology, Harbin, 150080, China.
Anal Chim Acta ; 1316: 342820, 2024 Aug 08.
Article em En | MEDLINE | ID: mdl-38969422
ABSTRACT
This research presents an innovative reflective fiber optic probe structure, mutinously designed to detect H7N9 avian influenza virus gene precisely. This innovative structure skillfully combines multimode fiber (MMF) with a thin-diameter seven-core photonic crystal fiber (SCF-PCF), forming a semi-open Fabry-Pérot (FPI) cavity. This structure has demonstrated exceptional sensitivity in light intensity-refractive index (RI) response through rigorous theoretical and experimental validation. The development of a quasi-distributed parallel sensor array, which provides temperature compensation during measurements, has achieved a remarkable RI response sensitivity of up to 532.7 dB/RIU. The probe-type fiber optic sensitive unit, expertly functionalized with streptavidin, offers high specificity in detecting H7N9 avian influenza virus gene, with an impressively low detection limit of 10-2 pM. The development of this biosensor marks a significant development in biological detection, offering a practical engineering solution for achieving high sensitivity and specificity in light-intensity-modulated biosensing. Its potential for wide-ranging applications in various fields is now well-established.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Temperatura / Técnicas Biossensoriais / Subtipo H7N9 do Vírus da Influenza A Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Temperatura / Técnicas Biossensoriais / Subtipo H7N9 do Vírus da Influenza A Idioma: En Ano de publicação: 2024 Tipo de documento: Article