Your browser doesn't support javascript.
loading
Neurobehavioral, neurotransmitter and redox modifications in Nauphoeta cinerea under mixed heavy metal (silver and mercury) exposure.
Olagoke, Olawande C; Ogunsuyi, Opeyemi B; Mayokun, Famutimi E; Rocha, João B T; Oboh, Ganiyu.
Afiliação
  • Olagoke OC; Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. olawande.olagoke@kiu.ac.ug.
  • Ogunsuyi OB; Division of Translational Research and Technology Innovation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. olawande.olagoke@kiu.ac.ug.
  • Mayokun FE; Department of Physiology, Kampala International University, Ishaka-Bushenyi, Uganda. olawande.olagoke@kiu.ac.ug.
  • Rocha JBT; Department of Biomedical Technology, Federal University of Technology, P.M.B. 704, Akure, Nigeria.
  • Oboh G; Drosophila Research Lab, Functional Foods and Nutraceuticals Unit, Federal University of Technology, P.M.B. 704, Akure, Nigeria.
BMC Res Notes ; 17(1): 188, 2024 Jul 05.
Article em En | MEDLINE | ID: mdl-38970085
ABSTRACT
Heavy metals are encountered in nature, and are used in several human endeavors, including in dental fillings. It is well known that the safety of metals depends on their chemical form, as well as the dose and route through which biological systems are exposed to them. Here, we used the Nauphoeta cinerea model to examine the mechanism by which salts of the heavy metals used in dental fillings - silver and mercury - exert their neurotoxicity. Nymphs exposed to heavy metals presented with reduced motor and exploratory abilities as they spent more time immobile, especially in the periphery of a novel object, and covered less distance compared with control nymphs. Exposure to AgNO3 and HgCl2 also exacerbated levels of oxidative stress markers (MDA & ROS) and the neurotransmitter regulators - AChE and MAO, while reducing antioxidant activity markers, both in biochemical (thiol & GST) and RT-qPCR (TRX, GST, SOD, Catalase) examinations, in neural tissues of the cockroach. The observed disruptions in neurolocomotor control, synaptic transmission and redox balance explain how heavy metal salts may predispose organisms to neurological disorders.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredução / Estresse Oxidativo Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredução / Estresse Oxidativo Idioma: En Ano de publicação: 2024 Tipo de documento: Article