Overview of chromatin regulatory processes during surface ectodermal development and homeostasis.
Dev Biol
; 515: 30-45, 2024 Nov.
Article
em En
| MEDLINE
| ID: mdl-38971398
ABSTRACT
The ectoderm is the outermost of the three germ layers of the early embryo that arise during gastrulation. Once the germ layers are established, the complex interplay of cellular proliferation, differentiation, and migration results in organogenesis. The ectoderm is the progenitor of both the surface ectoderm and the neural ectoderm. Notably, the surface ectoderm develops into the epidermis and its associated appendages, nails, external exocrine glands, olfactory epithelium, and the anterior pituitary. Specification, development, and homeostasis of these organs demand a tightly orchestrated gene expression program that is often dictated by epigenetic regulation. In this review, we discuss the recent discoveries that have highlighted the importance of chromatin regulatory mechanisms mediated by transcription factors, histone and DNA modifications that aid in the development of surface ectodermal organs and maintain their homeostasis post-development.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Regulação da Expressão Gênica no Desenvolvimento
/
Ectoderma
/
Homeostase
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article