Microglia are dispensable for experience-dependent refinement of mouse visual circuitry.
Nat Neurosci
; 27(8): 1462-1467, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38977886
ABSTRACT
To test the hypothesized crucial role of microglia in the developmental refinement of neural circuitry, we depleted microglia from mice of both sexes with PLX5622 and examined the experience-dependent maturation of visual circuitry and function. We assessed retinal function, receptive field tuning of visual cortex neurons, acuity and experience-dependent plasticity. None of these measurements detectibly differed in the absence of microglia, challenging the role of microglia in sculpting neural circuits.
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1
Base de dados:
MEDLINE
Assunto principal:
Córtex Visual
/
Microglia
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article