Iron-catalyzed C-7 selective NH2 amination of indoles.
Angew Chem Int Ed Engl
; : e202412103, 2024 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-38979667
ABSTRACT
7-Aminoindoles are important synthetic intermediates to a broad range of bioactive molecules. Transition metal-catalyzed directed C-H amination is among the most straightforward route for their synthesis, whereas methods that could directly incorporate an NH2 group in a highly selective manner remains elusive. Moreover, there is still high demand for the development of earth-abundant metal catalysis for such attractive reactivity. We present here the first C-7 selective NH2 amination of indoles through a directed homolytic aromatic substitution (HAS) with iron-aminyl radical. The reaction exhibits broad substrate scope, tolerates variety of functional groups, and is readily scalable with catalyst loading down to 0.1 mol% and turnover number (TON) up to 4500.
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MEDLINE
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En
Ano de publicação:
2024
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Article