Harnessing cGAS-STING axis for therapeutic benefits in systemic lupus erythematosus.
Int J Rheum Dis
; 27(7): e15256, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38982864
ABSTRACT
The cyclic GMP-AMP synthase (cGAS), a prominent intracellular DNA sensor in mammalian cells, controls the innate immune response and the stimulator of interferon genes (STING)-mediated synthesis of pro-inflammatory cytokines, such as type-I interferon (IFN-I). For decades, IFN-I has been hypothesized to be essential in the development of systemic lupus erythematosus (SLE), a chronic multisystem autoimmunity characterized by immune complex (IC) deposition in small vessels. Recent findings revealed that the activation of the cGAS-STING pathway by self-DNA would propagate the autoimmune responses via upregulating IFN-I production in SLE. In this review, we aimed to provide a comprehensive outlook of the role of the cGAS-STING pathway in SLE pathobiology, as well as, a better understanding of current therapeutic opportunities targeting this axis.
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Lúpus Eritematoso Sistêmico
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Proteínas de Membrana
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Nucleotidiltransferases
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article