VISTA: A promising target for overcoming immune evasion in gynecologic cancers.
Int Immunopharmacol
; 138: 112655, 2024 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-38986302
ABSTRACT
Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment but has shown limited efficacy in gynecologic cancers. VISTA (V-domain Ig suppressor of T-cell activation), a member of the B7 family, is emerging as another checkpoint that regulates the anti-tumor immune responses within the tumor microenvironment. This paper reviews the structure, expression, and mechanism of action of VISTA. Furthermore, it highlights recent advances in VISTA-blocking therapies and their potential in improving outcomes for patients with gynecologic cancers. By understanding the role of VISTA in mediating the immune evasion of gynecologic tumors, we can develop more effective combinatory treatment strategies that could overcome resistance to current ICB therapies.
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Base de dados:
MEDLINE
Assunto principal:
Evasão Tumoral
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Microambiente Tumoral
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Antígenos B7
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Inibidores de Checkpoint Imunológico
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Neoplasias dos Genitais Femininos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article