Multibiofunctional Self-healing Adhesive Injectable Nanocomposite Polysaccharide Hydrogel.
Biomacromolecules
; 25(8): 4762-4779, 2024 Aug 12.
Article
em En
| MEDLINE
| ID: mdl-38989826
ABSTRACT
Injectable hydrogels with good antimicrobial and antioxidant properties, self-healing characteristics, suitable mechanical properties, and therapeutic effects have great practical significance for developing treatments for pressing healthcare challenges. Herein, we have designed a novel, self-healing injectable hydrogel composite incorporating cross-linked biofunctional nanomaterials by mixing alginate aldehyde (Ox-Alg), quaternized chitosan (QCS), adipic acid dihydrazide (ADH), and copper oxide nanosheets surface functionalized with folic acid as the bioligand (F-CuO). Gelation was achieved under physiological conditions via the dynamic Schiff base cross-linking mechanism. The developed nanocomposite injectable hydrogel demonstrated the fast self-healing ability essential to bear deformation and outstanding antibacterial properties along with ROS scavenging ability. Furthermore, the optimized formulation of our F-CuO-embedded injectable hydrogel exhibited excellent cytocompatibility, blood compatibility, and in vitro wound healing performance. Taken together, the F-CuO nanosheet cross-linked injectable hydrogel composite presented herein offers a promising candidate biomaterial with multifunctional properties to develop solutions for addressing clinical challenges.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Hidrogéis
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Quitosana
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Nanocompostos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article