Meta-analysis and systematic review of gout prevalence in the heart/lung transplantation population.
Front Transplant
; 3: 1356058, 2024.
Article
em En
| MEDLINE
| ID: mdl-38993785
ABSTRACT
Introduction:
Gout may complicate solid organ transplantation with potentially serious consequences. An accurate prevalence of gout in this population is unknown.Objectives:
This study aimed to estimate the prevalence of gout in the heart and/or lung transplantation population through a systematic review and meta-analysis.Methods:
MEDLINE, Embase, PsycINFO, CENTRAL and Cochrane Library (inception to February 2022) were searched for studies that reported the prevalence and/or incidence of gout in heart and/or lung transplant recipients. Two authors extracted outcomes data. Data were pooled using a random effects model. Overall quality of evidence was assessed using GRADE. Primary outcomes were the prevalence of pre- or post-transplant gout expressed as a prevalence rate (95% CI). Secondary outcomes included risk factors for gout, adverse events, and therapeutic complications of gout treatment.Results:
Ten studies were included. Gout prevalence (PR) was 8% pre-transplant (PR = 0.08; 95% CI 0.05-0.12; 4 studies n = 651) and 6% post-transplant (PR = 0.06; 95% CI 0.06-0.06; 10 studies n = 45,298). Post-transplant gout prevalence in heart transplant recipients was almost three times higher than lung transplant recipients (PR = 0.16; 95% CI 0.13-0.20 vs. PR = 0.06; 95% CI 0.05-0.06 respectively). Patients with a pre-transplant history of gout had a higher risk of developing post-transplant gout than patients without (RR = 3.61; 95% CI 2.19-5.95). Factors associated with gout and outcomes for heart and/or lung transplant recipients with gout were comprehensively reviewed from the included studies.Conclusion:
Gout is highly prevalent in heart and/or lung transplant patients. Pre-transplant gout is predictive of developing symptomatic post-transplant gout. This has significant implications for management of heart/lung transplant patients. Systematic Review Registration https//www.crd.york.ac.uk/, PROSPERO (CRD42020190632).
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article