Your browser doesn't support javascript.
loading
Self-reporting intracellular delivery agent for singlet oxygen.
Li, Yiran; Wang, Lei; Zhang, Shengli; Liu, Ziang; Sun, Rensong; Qiao, Yuan; Akkaya, Engin U.
Afiliação
  • Li Y; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, P. R. China. leiwang@dlut.edu.cn.
  • Wang L; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, P. R. China. leiwang@dlut.edu.cn.
  • Zhang S; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, P. R. China. leiwang@dlut.edu.cn.
  • Liu Z; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, P. R. China. leiwang@dlut.edu.cn.
  • Sun R; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, P. R. China. leiwang@dlut.edu.cn.
  • Qiao Y; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, P. R. China. leiwang@dlut.edu.cn.
  • Akkaya EU; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, P. R. China. leiwang@dlut.edu.cn.
Chem Commun (Camb) ; 60(62): 8111-8114, 2024 Jul 30.
Article em En | MEDLINE | ID: mdl-38994648
ABSTRACT
1,4-Dimethylphenazine endoperoxide releases singlet oxygen with a half-life of 89 hours at 37 °C. The thermal cycloreversion reaction is accompanied by a strong increase in the emission intensity with a peak at 490 nm, due to the formation of the phenazine core. The endoperoxide is effective against cancer cells in culture medium and tumor spheroids, with singlet oxygen-mediated cytotoxicity.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenazinas / Oxigênio Singlete Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenazinas / Oxigênio Singlete Idioma: En Ano de publicação: 2024 Tipo de documento: Article