Calorie restriction in mice impairs cortical but not trabecular peak bone mass by suppressing bone remodeling.
J Bone Miner Res
; 39(8): 1188-1199, 2024 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-38995944
Calorie restriction led to impaired bone mass and increased accumulation of bone marrow adipose tissue. During the development of bone-fat imbalance due to calorie restriction, bone remodeling was notably inhibited. Calorie restriction may shift the differentiation of bone marrow stem cells toward adipocytes instead of osteoblasts. This process involves a disruption in the canonical Wnt signaling pathway.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Densidade Óssea
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Remodelação Óssea
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Restrição Calórica
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Osso Esponjoso
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Osso Cortical
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article