A 3-year follow-up analysis of renal function in elderly patients with type 2 diabetes mellitus and an estimated glomerular filtration rate <90 mL/min/1.73m2: A retrospective cohort study.
Medicine (Baltimore)
; 103(28): e38865, 2024 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-38996107
ABSTRACT
Type 2 diabetes mellitus (T2DM) is a risk factor for patients with impaired renal function. The onset of T2DM-induced diabetic kidney disease (DKD) is frequently sub-clinical, potentially culminating in end-stage renal disease. In the current study the factors influencing DKD in elderly patients diagnosed with T2DM were determined. A retrospective cohort study was conducted involving patients ≥60 years of age with T2DM from June 2019 to December 2022. The Cockcroft-Gault formula was used to estimate the glomerular filtration rate. The clinical information and biochemical indicators of patients with an estimated glomerular filtration rate (eGFR)â
<â
90 mL/min/1.73m2 were collected. Patients were grouped based on a 3-year eGFR declineâ
<â
15% andâ
≥â
15%. The differences between the two groups were compared and the factors influencing the 3-year eGFR declineâ
≥â
15% were analyzed. A total of 242 patients were included, including 154 in the group with a 3-year eGFR declineâ
<â
15% and 88 in the group with a three-year eGFR declineâ
≥â
15%. Univariate logistic regression analysis showed that smoking cigarettes, and triglycerides (TG) and high-density lipoprotein levels were related to a 3-year eGFR declineâ
≥â
15% (Pâ
=â
.039, Pâ
<â
.001, and Pâ
=â
.011, respectively). Multivariate logistic regression analysis showed that the TG level was independently related to a 3-year eGFR declineâ
≥â
15% (Pâ
=â
.004; ORâ
=â
2.316). There was a significant linear relationship between the eGFR decline and TG level (Pâ
=â
.002). Patients with a TG concentrationâ
>â
1.7 mmol/L had a more apparent decrease in the eGFR (Pâ
<â
.05). For elderly patients with T2DM and an eGFRâ
<â
90 mL/min/1.73m2, the TG level may be an important risk factor for deteriorating renal function that warrants actively intervention.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
/
Nefropatias Diabéticas
/
Taxa de Filtração Glomerular
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article