Ubiquitous purine sensor modulates diverse signal transduction pathways in bacteria.
Nat Commun
; 15(1): 5867, 2024 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-38997289
ABSTRACT
Purines and their derivatives control intracellular energy homeostasis and nucleotide synthesis, and act as signaling molecules. Here, we combine structural and sequence information to define a purine-binding motif that is present in sensor domains of thousands of bacterial receptors that modulate motility, gene expression, metabolism, and second-messenger turnover. Microcalorimetric titrations of selected sensor domains validate their ability to specifically bind purine derivatives, and evolutionary analyses indicate that purine sensors share a common ancestor with amino-acid receptors. Furthermore, we provide experimental evidence of physiological relevance of purine sensing in a second-messenger signaling system that modulates c-di-GMP levels.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Proteínas de Bactérias
/
Transdução de Sinais
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article