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Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo-Inorganic Structures.
Lee, Jin Woong; Lee, Byoungsang; Park, Cheol Hyun; Heo, Jun Hyuk; Lee, Tae Yoon; Lee, Dongtak; Bae, Jina; Sundharbaabu, Priyannth Ramasami; Yeom, Won Kyun; Chae, Sudong; Lim, Jae-Hyuk; Lee, Seok-Won; Choi, Jin-Seok; Bae, Hyung-Bin; Choi, Jae-Young; Lee, Eun-Ho; Yoon, Dae Sung; Yeom, Geun Young; Shin, Hyunjung; Lee, Jung Heon.
Afiliação
  • Lee JW; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Lee B; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Park CH; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Heo JH; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Lee TY; Research Center for Advanced Materials Technology, SKKU, Suwon, 16419, Republic of Korea.
  • Lee D; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Bae J; School of Biomedical Engineering, Korea University, Seoul, 02841, Republic of Korea.
  • Sundharbaabu PR; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Yeom WK; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Chae S; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Lim JH; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Lee SW; School of Mechanical Engineering, SKKU, Suwon, 16419, Republic of Korea.
  • Choi JS; School of Mechanical Engineering, SKKU, Suwon, 16419, Republic of Korea.
  • Bae HB; Analysis Center for Research Advancement, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
  • Choi JY; Analysis Center for Research Advancement, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
  • Lee EH; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Yoon DS; School of Mechanical Engineering, SKKU, Suwon, 16419, Republic of Korea.
  • Yeom GY; School of Biomedical Engineering, Korea University, Seoul, 02841, Republic of Korea.
  • Shin H; School of Advanced Materials Science & Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
  • Lee JH; Department of Energy Science, SKKU, Suwon, 16419, Republic of Korea.
Adv Mater ; 36(41): e2406179, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39003621
ABSTRACT
Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented. The synthesized DNApatite, DNA1Ca2.2(PO4)1.3OH2.1, has a repetitive dual phase of inorganic HA crystals and amorphous organic ssDNA at the sub-nm scale, forming nanorods. Its mechanical properties, including toughness and elasticity, are significantly enhanced compared with those of HA nanorod, with a Young's modulus similar to that of natural bone.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article