[Endocrine function of the pancreas in tumors of the chiasmal-sellar region]. / Sostoianie endokrinnoi funktsii podzheludochnoi zhelezy pri opukholiakh khiazmal'no-selliarnoi oblasti.
Probl Endokrinol (Mosk)
; 31(4): 9-13, 1985.
Article
em Ru
| MEDLINE
| ID: mdl-3900983
ABSTRACT
A clinicobiochemical study of 10 patients with tumors of the chiasmal sellar region and 8 healthy persons using the i. v. glucose tolerance test (IGTT) made it possible to reveal disorder of pancreatic alpha- and beta-cell function in the patients with tumors. A distinct picture of the chiasmal sellar process with the involved hypothalamus was clinically determined in all the patients. Radioimmunoassay of immunoreactive insulin, glucagon, C-peptide and glucose revealed fasting hyperinsulinemia in the presence of both hypo- and hyperglycemia. The latter was accompanied by a raised level of glucagon in the blood. The IGTT revealed in the patients with tumors of the chiasmal sellar region hyperreactivity of beta-cells and a decrease in the sensitivity of alpha-cells to glucose as well as glucose tolerance that may be both regarded as pathogenetic factors of the development of a prediabetic condition in such patients.
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Base de dados:
MEDLINE
Assunto principal:
Quiasma Óptico
/
Neoplasias Hipofisárias
/
Ilhotas Pancreáticas
/
Neoplasias dos Nervos Cranianos
/
Insulina
Idioma:
Ru
Ano de publicação:
1985
Tipo de documento:
Article