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The potential anti-arrhythmic effect of SGLT2 inhibitors.
Duan, Hong-Yi; Barajas-Martinez, Hector; Antzelevitch, Charles; Hu, Dan.
Afiliação
  • Duan HY; Department of Cardiology and Cardiovascular Research Institute, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China.
  • Barajas-Martinez H; Hubei Key Laboratory of Cardiology, Wuhan, 430060, Hubei, China.
  • Antzelevitch C; Lankenau Institute for Medical Research, Lankenau Heart Institute, Wynnewood, PA, 19096, USA.
  • Hu D; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, 19107, USA.
Cardiovasc Diabetol ; 23(1): 252, 2024 Jul 15.
Article em En | MEDLINE | ID: mdl-39010053
ABSTRACT
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) were initially recommended as oral anti-diabetic drugs to treat type 2 diabetes (T2D), by inhibiting SGLT2 in proximal tubule and reduce renal reabsorption of sodium and glucose. While many clinical trials demonstrated the tremendous potential of SGLT2i for cardiovascular diseases. 2022 AHA/ACC/HFSA guideline first emphasized that SGLT2i were the only drug class that can cover the entire management of heart failure (HF) from prevention to treatment. Subsequently, the antiarrhythmic properties of SGLT2i have also attracted attention. Although there are currently no prospective studies specifically on the anti-arrhythmic effects of SGLT2i. We provide clues from clinical and fundamental researches to identify its antiarrhythmic effects, reviewing the evidences and mechanism for the SGLT2i antiarrhythmic effects and establishing a novel paradigm involving intracellular sodium, metabolism and autophagy to investigate the potential mechanisms of SGLT2i in mitigating arrhythmias.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Diabetes Mellitus Tipo 2 / Inibidores do Transportador 2 de Sódio-Glicose / Antiarrítmicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Diabetes Mellitus Tipo 2 / Inibidores do Transportador 2 de Sódio-Glicose / Antiarrítmicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article