Paper-based Electrochemical Sensor Integrated with Gold Nanoparticle-Decorated Carbon Cloth as a Working Electrode for Nitric Oxide Detection in Artificial Tears.
ACS Appl Bio Mater
; 7(8): 5247-5257, 2024 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-39010742
ABSTRACT
Nitric oxide (NO) in human tears regulates numerous ocular surface processes, such as tear generation, corneal wound healing, conjunctival vascular tone, and so forth. Any deviation from its normal concentration is linked to various ocular syndromes, including microbial keratitis, conjunctivitis, pterygium, dry eye, retinitis, glaucoma, and so forth. Therefore, precise monitoring of NO in tears can be considered as a potential biomarker for ocular diseases. Here, we report a highly sensitive and selective electrochemical NO sensor using carbon ink-based electrodes. Counter, working (WE), and reference electrodes have been designed and painted on a butter paper by using carbon ink. To improve the sensing performance, the WE has been modified with a gold nanoparticle (Au NP)-deposited carbon cloth (CC). Such a paper-based sensor demonstrated high sensitivity of â¼0.34 µA µM-1 cm-2, ultralow detection limit of â¼2.35 nM, wide linear range of 10 nM-0.4 mM, and fast response time (0.35 s). The sensor also showed excellent stability and selectivity toward the interfering agents in human body fluids. Such a low-cost, flexible paper-based sensor was employed for the detection of NO in artificial tears.
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Base de dados:
MEDLINE
Assunto principal:
Papel
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Tamanho da Partícula
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Materiais Biocompatíveis
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Carbono
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Eletrodos
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Nanopartículas Metálicas
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Técnicas Eletroquímicas
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Ouro
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Óxido Nítrico
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article