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Ticking Brain: Circadian Rhythm as a New Target for Cerebroprotection.
Xu, Shuaili; Jia, Milan; Guo, Jiaqi; He, Jiachen; Chen, Xi; Xu, Yi; Hu, Wenbo; Wu, Di; Wu, Chuanjie; Ji, Xunming.
Afiliação
  • Xu S; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China. (S.X., X.J.).
  • Jia M; China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China. (S.X., J.G., J.H., X.C., Y.X., W.H., D.W., X.J.).
  • Guo J; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. (M.J., X.C., Y.X., W.H., C.W., X.J.).
  • He J; China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China. (S.X., J.G., J.H., X.C., Y.X., W.H., D.W., X.J.).
  • Chen X; China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China. (S.X., J.G., J.H., X.C., Y.X., W.H., D.W., X.J.).
  • Xu Y; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. (M.J., X.C., Y.X., W.H., C.W., X.J.).
  • Hu W; China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China. (S.X., J.G., J.H., X.C., Y.X., W.H., D.W., X.J.).
  • Wu D; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. (M.J., X.C., Y.X., W.H., C.W., X.J.).
  • Wu C; China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China. (S.X., J.G., J.H., X.C., Y.X., W.H., D.W., X.J.).
  • Ji X; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. (M.J., X.C., Y.X., W.H., C.W., X.J.).
Stroke ; 2024 Jul 16.
Article em En | MEDLINE | ID: mdl-39011642
ABSTRACT
Circadian rhythm is a master process observed in nearly every type of cell throughout the body, and it macroscopically regulates daily physiology. Recent clinical trials have revealed the effects of circadian variation on the incidence, pathophysiological processes, and prognosis of acute ischemic stroke. Furthermore, core clock genes, the cell-autonomous pacemakers of the circadian rhythm, affect the neurovascular unit-composing cells in a nonparallel manner after the same pathophysiological processes of ischemia/reperfusion. In this review, we discuss the influence of circadian rhythms and clock genes on each type of neurovascular unit cell in the pathophysiological processes of acute ischemic stroke.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article