Optimization of atorvastatin and quercetin-loaded solid lipid nanoparticles using Box-Behnken design.
Nanomedicine (Lond)
; 19(17): 1541-1555, 2024 07 14.
Article
em En
| MEDLINE
| ID: mdl-39012199
ABSTRACT
Aim:
The study explores the synergistic potential of atorvastatin (ATR) and quercetin (QUER)- loaded solid lipid nanoparticles (SLN) in combating breast cancer. Materials &methods:
SLNs were synthesized using a high-shear homogenization method and optimized using Box-Behnken design. The SLNs were characterized and evaluated for their in vitro anticancer activity.Results:
The optimized SLN exhibited narrow size distribution (PDI = 0.338 ± 0.034), a particle size of 72.5 ± 6.5 nm, higher entrapment efficiency (<90%), sustained release and spherical surface particles. The in vitro cytotoxicity studies showed a significant reduction in IC50 values on MDA-MB-231 cell lines.Conclusion:
We report a novel strategy of repurposing well-known drugs and encapsulating them into SLNs as a promising drug-delivery system against breast cancer.
[Box see text].
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tamanho da Partícula
/
Quercetina
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Neoplasias da Mama
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Nanopartículas
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Atorvastatina
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article