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The positive role of transforming growth factor-ß1 in ischemic stroke.
Li, Zi-Rong; Wang, Yong-Yan; Wang, Zi-Han; Qin, Qi-Lin; Huang, Cheng; Shi, Guang-Sen; He, Hong-Yun; Deng, Yi-Hao; He, Xiu-Ying; Zhao, Xiao-Ming.
Afiliação
  • Li ZR; Faculty of Medicine, Kunming University of Science and Technology, Kunming, China. Electronic address: 202010708127@kust.edu.cn.
  • Wang YY; Faculty of Medicine, Kunming University of Science and Technology, Kunming, China. Electronic address: 202112601251@kust.edu.cn.
  • Wang ZH; Faculty of Medicine, Kunming University of Science and Technology, Kunming, China. Electronic address: 202112601240@kust.edu.cn.
  • Qin QL; Faculty of Medicine, Kunming University of Science and Technology, Kunming, China. Electronic address: 202010407135@kust.edu.cn.
  • Huang C; Faculty of Medicine, Kunming University of Science and Technology, Kunming, China. Electronic address: 202014506224@kust.edu.cn.
  • Shi GS; Faculty of Medicine, Kunming University of Science and Technology, Kunming, China. Electronic address: 202112601302@kust.edu.cn.
  • He HY; Faculty of Medicine, Kunming University of Science and Technology, Kunming, China; Anning First People's Hospital Affiliated to Kunming University of Science and Technology, Kunming, China. Electronic address: 20130211@kust.edu.cn.
  • Deng YH; Faculty of Medicine, Kunming University of Science and Technology, Kunming, China. Electronic address: 20130117@kust.edu.cn.
  • He XY; Department of Anesthesiology, Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu, China. Electronic address: hxyscientific@wchscu.edu.cn.
  • Zhao XM; Faculty of Medicine, Kunming University of Science and Technology, Kunming, China; Anning First People's Hospital Affiliated to Kunming University of Science and Technology, Kunming, China. Electronic address: 20190064@kust.edu.cn.
Cell Signal ; 121: 111301, 2024 Sep.
Article em En | MEDLINE | ID: mdl-39019338
ABSTRACT
Ischemic stroke is one of the most disabling and fatal diseases around the world. The damaged brain tissues will undergo excessive autophagy, vascular endothelial cells injury, blood-brain barrier (BBB) impairment and neuroinflammation after ischemic stroke. However, there is no unified viewpoint on the underlying mechanism of brain damage. Transforming growth factor-ß1 (TGF-ß1), as a multi-functional cytokine, plays a crucial role in the intricate pathological processes and helps maintain the physiological homeostasis of brain tissues through various signaling pathways after ischemic stroke. In this review, we summarize the protective role of TGF-ß1 in autophagic flux, BBB, vascular remodeling, neuroinflammation and other aspects after ischemic stroke. Based on the review, we believe that TGF-ß1 could serve as a key target for treating ischemic stroke.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Barreira Hematoencefálica / Fator de Crescimento Transformador beta1 / AVC Isquêmico Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Barreira Hematoencefálica / Fator de Crescimento Transformador beta1 / AVC Isquêmico Idioma: En Ano de publicação: 2024 Tipo de documento: Article