The positive role of transforming growth factor-ß1 in ischemic stroke.
Cell Signal
; 121: 111301, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39019338
ABSTRACT
Ischemic stroke is one of the most disabling and fatal diseases around the world. The damaged brain tissues will undergo excessive autophagy, vascular endothelial cells injury, blood-brain barrier (BBB) impairment and neuroinflammation after ischemic stroke. However, there is no unified viewpoint on the underlying mechanism of brain damage. Transforming growth factor-ß1 (TGF-ß1), as a multi-functional cytokine, plays a crucial role in the intricate pathological processes and helps maintain the physiological homeostasis of brain tissues through various signaling pathways after ischemic stroke. In this review, we summarize the protective role of TGF-ß1 in autophagic flux, BBB, vascular remodeling, neuroinflammation and other aspects after ischemic stroke. Based on the review, we believe that TGF-ß1 could serve as a key target for treating ischemic stroke.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Barreira Hematoencefálica
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Fator de Crescimento Transformador beta1
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AVC Isquêmico
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article