Proteasome isoforms in human thymi and mouse models.
Immunol Lett
; 269: 106899, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39019403
ABSTRACT
The thymus is the organ where functional and self-tolerant T cells are selected through processes of positive and negative selection before migrating to the periphery. The antigenic peptides presented on MHC class I molecules of thymic epithelial cells (TECs) in the cortex and medulla of the thymus are key players in these processes. It has been theorized that these cells express different proteasome isoforms, which generate MHC class I immunopeptidomes with features that differentiate cortex and medulla, and hence positive and negative CD8+ T cell selection. This theory is largely based on mouse models and does not consider the large variety of noncanonical antigenic peptides that could be produced by proteasomes and presented on MHC class I molecules. Here, we review the multi-omics, biochemical and cellular studies carried out on mouse models and human thymi to investigate their content of proteasome isoforms, briefly summarize the implication that noncanonical antigenic peptide presentation in the thymus could have on CD8+ T cell repertoire and put these aspects in the larger framework of anatomical and immunological differences between these two species.
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Base de dados:
MEDLINE
Assunto principal:
Timo
/
Isoformas de Proteínas
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Complexo de Endopeptidases do Proteassoma
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article