Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.

Li, Wenzhuo; Zhou, Qingtong; Cong, Zhaotong; Yuan, Qingning; Li, Wenxin; Zhao, Fenghui; Xu, H Eric; Zhao, Li-Hua; Yang, Dehua; Wang, Ming-Wei.

Afiliação

Li W; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Zhou Q; The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Cong Z; University of Chinese Academy of Sciences, Beijing, China.
Yuan Q; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Li W; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zhao F; State Key Laboratory of Drug Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Xu HE; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zhao LH; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Yang D; The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Wang MW; University of Chinese Academy of Sciences, Beijing, China.

Cell Discov ; 10(1): 77, 2024 Jul 17.

Article em En | MEDLINE | ID: mdl-39019866

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article