Protective Effects of Hydrogen-rich Water Intake on Renal Injury in Neonatal Rats with High Oxygen Loading.
Juntendo Iji Zasshi
; 68(3): 235-241, 2022.
Article
em En
| MEDLINE
| ID: mdl-39021721
ABSTRACT
Objectives:
This study aimed to investigate the protective effects of hydrogen-rich water (HW) intake on renal injury in neonatal rats with high oxygen loading. Materials We used pregnant and newborn Sprague-Dawley rats.Methods:
Four groups were set up, with mother and newborn rats immediately after delivery as one group RA-PW (room air and purified water), RA-HW (room air and HW), O2-PW (80% oxygen and purified water), and O2-HW (80% oxygen and HW). The newborn rats were maintained in either a normoxic (room air, 21% oxygen) or controlled hyperoxic (80% oxygen) environment from birth. Then, HW (O2-HW and RA-HW groups) or PW (O2-PW and RA-PW groups) was administered to parents of each group.Results:
The number of immature glomeruli significantly increased in the O2-PW group (exposed to hyperoxia). Conversely, the O2-HW group had significantly fewer immature glomeruli than O2-PW group. In the RT-PCR analysis of kidney tissue, α-SMA, TGF-ß, and TNF-α levels were significantly higher in the O2-PW group than in the RA-PW group and significantly lower in the O2-HW group than in the O2-PW group.Conclusions:
HW intake can potentially reduce oxidative stress and prevent renal injury in neonates with high oxygen loading.
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MEDLINE
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En
Ano de publicação:
2022
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Article