Enantioselective Copper-Catalyzed Sequential Hydrosilylation of Arylmethylenecyclopropanes.
Angew Chem Int Ed Engl
; : e202407391, 2024 Jul 18.
Article
em En
| MEDLINE
| ID: mdl-39023320
ABSTRACT
Despite impressive advances in the construction of enantioenriched silacarbocycles featuring silicon-stereogenic centers via a selection of well-defined sila-synthons, the development of a more convenient and economic method with readily available starting materials is significantly less explored and remains a considerable challenge. Herein, we report the first example of copper-catalyzed sequential hydrosilylation of readily accessible methylenecyclopropanes (MCPs) and primary silanes, affording an efficient and convenient route to a wide range of chiral silacyclopentanes bearing consecutive silicon- and carbon-stereogenic centers with excellent enantio- and diastereoselectivities (generally ≥98% ee, > 251 dr). Mechanistic studies reveal that these reactions combine copper-catalyzed intermolecular ring-opening hydrosilylation of aryl MCPs and intramolecular asymmetric hydrosilylation of the resultant Z/E mixture of homoallylic silanes.
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MEDLINE
Idioma:
En
Ano de publicação:
2024
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Article