[CGRP: from neuropeptide to the therapeutic target (background and pathophysiology)]. / CGRP: vom Neuropeptid zum therapeutischen Target (Hintergründe und Pathophysiologie).
Fortschr Neurol Psychiatr
; 92(7-08): 267-276, 2024 Jul.
Article
em De
| MEDLINE
| ID: mdl-39025056
ABSTRACT
Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine pathophysiology. The importance of CGRP in migraine became evident from numerous clinical studies investigating CGRP levels both interictally and ictally and reports on the efficacy of CGRP-based migraine therapies. In this paper, the above mentioned studies will be presented and the reader will be introduced to the development of CGRP-based medication. Finally, current study results on CGRP receptor antagonists, the so-called gepants, will be presented.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeo Relacionado com Gene de Calcitonina
/
Transtornos de Enxaqueca
Idioma:
De
Ano de publicação:
2024
Tipo de documento:
Article