Is JAK effective in treating recurrent SAPHO syndrome? TwHF might be a good choice.
Medicine (Baltimore)
; 103(29): e38848, 2024 Jul 19.
Article
em En
| MEDLINE
| ID: mdl-39029083
ABSTRACT
BACKGROUND:
Recently, JAKi has also been widely proved to be an effective alternative to conventional treatment for Synovitis acne pustulosis-hyperostosis-osteitis (SAPHO) cases, after failure of multiple drugs including those described above. But what to do when all these treatments fail? We report a case of remission from Tripterygium wilfordii Hook (TwHF) treatment.METHODS:
The patient was treated with nonsteroidal anti-inflammatory drugs, oral prednisone, minocycline, bisphosphonate injection, etanercept, and tofacitinib, but the symptoms did not change significantly. Treatment with TwHF (1.0 mg/kg/day, patient weight 60 kg) was started for 24 weeks.RESULTS:
After 50 months of unsatisfactory treatment, this patient was finally treated with herbal TwHF, and after 6 months of treatment, the patient's magnetic resonance imaging and inflammatory indexes were significantly improved, indicating that the disease had been better controlled.CONCLUSION:
In this study, TwHF was successful in treating a patient with refractory SAPHO syndrome who was refractory to multiple Western medications without significant adverse effects or toxicities, but further follow-up is needed to determine long-term efficacy. More case reports as well as clinical trials are still needed to confirm whether TwHF can effectively treat refractory SAPHO syndrome.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Hiperostose Adquirida
/
Tripterygium
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article