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The SIRT7-nucleolus connection in cancer: ARF enters the fray.
Tarighi, Shahriar; Kumari, Poonam; Vaquero, Alejandro; Braun, Thomas; Ianni, Alessandro.
Afiliação
  • Tarighi S; Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
  • Kumari P; Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
  • Vaquero A; Chromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain.
  • Braun T; Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
  • Ianni A; Member of The German Center for Lung Research (DZL), Member of The Cardio-Pulmonary Institute (CPI), Giessen, Germany.
Mol Cell Oncol ; 11(1): 2381287, 2024.
Article em En | MEDLINE | ID: mdl-39036727
ABSTRACT
The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ARF) within the nucleolus, aiding cancer progression. We propose that targeting nucleolar SIRT7 offers promise for new anti-cancer therapies.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article