BiRNN-DDI: A Drug-Drug Interaction Event Type Prediction Model Based on Bidirectional Recurrent Neural Network and Graph2Seq Representation.
J Comput Biol
; 2024 Jul 25.
Article
em En
| MEDLINE
| ID: mdl-39049806
ABSTRACT
Research on drug-drug interaction (DDI) prediction, particularly in identifying DDI event types, is crucial for understanding adverse drug reactions and drug combinations. This work introduces a Bidirectional Recurrent Neural Network model for DDI event type prediction (BiRNN-DDI), which simultaneously considers structural relationships and contextual information. Our BiRNN-DDI model constructs drug feature graphs to mine structural relationships. For contextual information, it transforms drug graphs into sequences and employs a two-channel structure, integrating BiRNN, to obtain contextual representations of drug-drug pairs. The model's effectiveness is demonstrated through comparisons with state-of-the-art models on two DDI event-type benchmarks. Extensive experimental results reveal that BiRNN-DDI surpasses other models in accuracy, AUPR, AUC, F1 score, Precision, and Recall metrics on both small and large datasets. Additionally, our model exhibits a lower parameter space, indicating more efficient learning of drug feature representations and prediction of potential DDI event types.
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MEDLINE
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En
Ano de publicação:
2024
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Article