An intestinal TH17 cell-derived subset can initiate cancer.
Nat Immunol
; 25(9): 1637-1649, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39060651
ABSTRACT
Approximately 25% of cancers are preceded by chronic inflammation that occurs at the site of tumor development. However, whether this multifactorial oncogenic process, which commonly occurs in the intestines, can be initiated by a specific immune cell population is unclear. Here, we show that an intestinal T cell subset, derived from interleukin-17 (IL-17)-producing helper T (TH17) cells, induces the spontaneous transformation of the intestinal epithelium. This subset produces inflammatory cytokines, and its tumorigenic potential is not dependent on IL-17 production but on the transcription factors KLF6 and T-BET and interferon-γ. The development of this cell type is inhibited by transforming growth factor-ß1 (TGFß1) produced by intestinal epithelial cells. TGFß signaling acts on the pretumorigenic TH17 cell subset, preventing its progression to the tumorigenic stage by inhibiting KLF6-dependent T-BET expression. This study therefore identifies an intestinal T cell subset initiating cancer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas com Domínio T
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Células Th17
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Fator 6 Semelhante a Kruppel
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Mucosa Intestinal
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article