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The Role of Fibroblasts in Skin Homeostasis and Repair.
Boraldi, Federica; Lofaro, Francesco Demetrio; Bonacorsi, Susanna; Mazzilli, Alessia; Garcia-Fernandez, Maria; Quaglino, Daniela.
Afiliação
  • Boraldi F; Department of Life Science, University of Modena and Reggio Emilia, 41125 Modena, Italy.
  • Lofaro FD; Department of Life Science, University of Modena and Reggio Emilia, 41125 Modena, Italy.
  • Bonacorsi S; Department of Life Science, University of Modena and Reggio Emilia, 41125 Modena, Italy.
  • Mazzilli A; Department of Life Science, University of Modena and Reggio Emilia, 41125 Modena, Italy.
  • Garcia-Fernandez M; Department of Human Physiology, Institute of Biomedical Investigation (IBIMA), University of Málaga, 29010 Málaga, Spain.
  • Quaglino D; Department of Life Science, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Biomedicines ; 12(7)2024 Jul 17.
Article em En | MEDLINE | ID: mdl-39062158
ABSTRACT
Fibroblasts are typical mesenchymal cells widely distributed throughout the human body where they (1) synthesise and maintain the extracellular matrix, ensuring the structural role of soft connective tissues; (2) secrete cytokines and growth factors; (3) communicate with each other and with other cell types, acting as signalling source for stem cell niches; and (4) are involved in tissue remodelling, wound healing, fibrosis, and cancer. This review focuses on the developmental heterogeneity of dermal fibroblasts, on their ability to sense changes in biomechanical properties of the surrounding extracellular matrix, and on their role in aging, in skin repair, in pathologic conditions and in tumour development. Moreover, we describe the use of fibroblasts in different models (e.g., in vivo animal models and in vitro systems from 2D to 6D cultures) for tissue bioengineering and the informative potential of high-throughput assays for the study of fibroblasts under different disease contexts for personalized healthcare and regenerative medicine applications.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article