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Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells.
Mukusheva, Gulim K; Jalmakhanbetova, Roza I; Shaibek, Altynay Zh; Nurmaganbetova, Manshuk S; Zhasymbekova, Aigerym R; Nurkenov, Oralgazy A; Akishina, Ekaterina A; Kolesnik, Irina A; Dikusar, Evgenij A; Terpinskaya, Tatiana I; Kulchitsky, Vladimir A; Potkin, Vladimir I; Pushkarchuk, Alexander L; Lyakhov, Dmitry A; Michels, Dominik L.
Afiliação
  • Mukusheva GK; Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan.
  • Jalmakhanbetova RI; Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan.
  • Shaibek AZ; Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan.
  • Nurmaganbetova MS; Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan.
  • Zhasymbekova AR; Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan.
  • Nurkenov OA; Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, Kazakhstan.
  • Akishina EA; Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
  • Kolesnik IA; Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
  • Dikusar EA; Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
  • Terpinskaya TI; Institute of Physiology, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
  • Kulchitsky VA; Institute of Physiology, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
  • Potkin VI; Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
  • Pushkarchuk AL; Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
  • Lyakhov DA; Computer, Electrical and Mathematical Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
  • Michels DL; Computer, Electrical and Mathematical Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
Molecules ; 29(14)2024 Jul 09.
Article em En | MEDLINE | ID: mdl-39064825
ABSTRACT
Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides / Simulação de Acoplamento Molecular / Glioma / Antineoplásicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides / Simulação de Acoplamento Molecular / Glioma / Antineoplásicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article