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Combined Theoretical and Experimental Investigations: Design, Synthesis, Characterization, and In Vitro Cytotoxic Activity Assessment of a Complex of a Novel Ureacellobiose Drug Carrier with the Anticancer Drug Carmustine.
Hoelm, Marta; Porwanski, Stanislaw; Józwiak, Pawel; Krzeslak, Anna.
Afiliação
  • Hoelm M; Theoretical and Structural Group, Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236 Lodz, Poland.
  • Porwanski S; Department of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland.
  • Józwiak P; Department of Cytobiochemistry, Faculty of Biology, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
  • Krzeslak A; Department of Cytobiochemistry, Faculty of Biology, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Molecules ; 29(14)2024 Jul 17.
Article em En | MEDLINE | ID: mdl-39064937
ABSTRACT
Drug delivery systems (DDSs) are used to transport drugs which are characterized by some pharmaceutical problems to the specific target site, enhancing therapeutic efficacy and reducing off-target accumulation in the body. In this work, one of the recently synthesized molecules, 1,10-N,N'-bis-(ß-ᴅ-ureidocellobiosyl)-4,7,13,16-tetraoxa-1,10-diazacyclooctadecane (TN), was tested as a potential drug carrier towards the anticancer drug carmustine. For this purpose, different techniques were used, from synthesis and calculations to cytotoxicity assessment. Our results showed that TN is characterized by a very compact geometry, which significantly impacts its complexation properties. Although it forms a very stable complex with carmustine, it adopts a non-inclusion geometry, as verified by both experimental and theoretical NMR analyses. The cytotoxicity study performed for all analyzed molecules (TN; carmustine; TNcarmustine complex) towards normal and cancer (breast and colon) cells revealed that TN is not toxic and that the formation of complexes with carmustine reduces the toxicity of carmustine to normal cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Carmustina / Antineoplásicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Carmustina / Antineoplásicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article