Physical properties and antioxidant activity of curcuminzinc metal-organic frameworks.
Food Chem
; 460(Pt 1): 140449, 2024 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-39067388
ABSTRACT
Metal-organic frameworks (MOFs) offer diverse applications in the food industry, facilitating loading, protection, and controlled release of functional ingredients despite encountering loading capacity and functional activity limitations. This study focuses on curcuminzinc MOFs, harnessing curcumin's renowned health benefits and zinc to enhance pharmacological properties. We evaluated their synthesis efficiency, stability under varying conditions (pH, salt concentration, temperature), loading and antioxidant capacity. The results showed that microwave synthesis yielded MOFs with a 23.2 ± 4.5% yield, stable within pH 4-10, gradually decomposing in PBS. DPPH, ABTS, and H2O2 assays revealed varying free radical scavenging abilities. MOFs disintegrate in either acidic environments or contain H2O2 (at a concentration threshold of 10 µM). Post-disintegration, these MOFs significantly inhibiting the secretion of TNF-α by RAW264.7 cells induced by LPS. These findings highlight the potential of novel curcuminzinc MOF materials for nutrient delivery, addressing challenges in effectively delivering functional ingredients.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Curcumina
/
Estruturas Metalorgânicas
/
Antioxidantes
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article