Discovery of aminopiperidine based potent & novel topoisomerase inhibitor with broad spectrum anti-bacterial activity.
Bioorg Med Chem Lett
; 111: 129911, 2024 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-39067715
ABSTRACT
Bacterial DNA gyrase and topoisomerase IV inhibition has emerged as a promising strategy for the cure of infections caused by antibiotic-resistant bacteria. The Novel Bacterial Topoisomerase Inhibitors (NBTIs) bind to a different site from that of the quinolones with novel mechanism of action. This evades the existing target-mediated bacterial resistance associated with quinolones. This article presents our efforts to identify in vitro potent and broad-spectrum antibacterial agent 4l.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Piperidinas
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Testes de Sensibilidade Microbiana
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Antibacterianos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article