The Efficacy and Safety of Complementary and Alternative Medicine for Depression: An Umbrella Review.

Liu, Yiting; Yang, Rongfei; Zhang, Nana; Liu, Qingshan

Liu, Yiting; Yang, Rongfei; Zhang, Nana; Liu, Qingshan.

Afiliação

Liu Y; Key Laboratory of Ethnomedicine of Ministry of Education, Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, Beijing, China.
Yang R; Key Laboratory of Ethnomedicine of Ministry of Education, Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, Beijing, China.
Zhang N; Key Laboratory of Ethnomedicine of Ministry of Education, Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, Beijing, China.
Liu Q; Key Laboratory of Ethnomedicine of Ministry of Education, Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, Beijing, China.

Braz J Psychiatry ; 2024 Jul 29.

Article em En | MEDLINE | ID: mdl-39074155

ABSTRACT

ABSTRACT

OBJECTIVE:

Depression is a major public health problem. Many complementary and alternative medicine (CAM) interventions have been suggested as potential treatments.

METHODS:

We comprehensively searched for relevant systematic reviews and meta-analyses in the PubMed, EMBASE, Web of Science, and Cochrane Library databases. We assessed effectiveness based on efficiency and changes in Depression Assessment Scale scores and safety based on adverse events.

RESULTS:

This umbrella review included twenty-two eligible articles. Yueju antidepressant and Electro-acupuncture (EA) improved depression symptoms better than antidepressants. In addition, omega-3 fatty acids (n-3PUFAs), exercise, manual acupuncture (MA), Hypericum mono-preparations, relaxation, and Vitamin D showed better efficacy than placebo and control. GPD as adjunctive therapies have higher efficacy rates than antidepressant, and MA and Yueju antidepressants have a better safety profile than antidepressants.