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Symptoms of autism in Williams syndrome: a transdiagnostic approach.
Willfors, Charlotte; Borg, Jacqueline; Kleberg, Johan Lundin; Hallman, Astrid; Van Der Poll, Marcus; Lundin Remnélius, Karl; Björlin Avdic, Hanna; Bölte, Sven; Nordgren, Ann.
Afiliação
  • Willfors C; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden. charlotte.willfors@ki.se.
  • Borg J; Department of Clinical Genetics and Genomics, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden. charlotte.willfors@ki.se.
  • Kleberg JL; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institute, Stockholm Health Care Services, Stockholm, Sweden.
  • Hallman A; Department of Clinical Neuroscience, Centre for Cognitive and Computational Neuropsychiatry, Karolinska Institute, Stockholm Health Care Services, Stockholm, Sweden.
  • Van Der Poll M; Neuropsychiatry, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Lundin Remnélius K; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institute, Stockholm Health Care Services, Stockholm, Sweden.
  • Björlin Avdic H; Department of Psychology, Stockholm University, Stockholm, Sweden.
  • Bölte S; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
  • Nordgren A; Department of Psychology, Stockholm University, Stockholm, Sweden.
Sci Rep ; 14(1): 17583, 2024 07 30.
Article em En | MEDLINE | ID: mdl-39080307
ABSTRACT
Williams syndrome (WS) is associated with atypical social communication and cognition reminiscent of the behaviours observed in autism. Nonetheless, WS also differs significantly from autism, such as regarding social motivation, which is typically enhanced in WS and reduced in autism. This study sought to examine the conditions' transdiagnostic similarities and differences for autistic symptoms and social functioning, and their developmental trajectories, by comparing individuals with WS (n = 24) and those diagnosed with idiopathic autism (n = 24) and attention deficit hyperactivity disorder (ADHD; n = 24), aged 9 to 53 years, on measures of autism, social functioning, IQ and cooccurring psychiatric conditions. Although only 12.5% in the WS group met the criteria for an autism diagnosis, a majority exhibited distinct difficulties within social communication, social cognition, repetitive behaviours, and atypical sensory reactivity resembling autism. Conversely, elevated social motivation and a high number of social initiatives accompany these characteristics. No group differences in the developmental trajectories of autism symptoms were found. Our results demonstrate that autistic behaviours are more frequent in individuals with WS, than in individuals with idiopathic ADHD, and emphasize the need for clinical management of these behaviours.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Síndrome de Williams Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Síndrome de Williams Idioma: En Ano de publicação: 2024 Tipo de documento: Article