Value of high-output pace-mapping of the right phrenic nerve for enabling safe radiofrequency ablation of atrial fibrillation: insights from three-dimensional computed tomography segmentation.
Europace
; 26(8)2024 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-39082747
ABSTRACT
AIMS:
Right phrenic nerve (RPN) injury is a disabling but uncommon complication of atrial fibrillation (AF) radiofrequency ablation. Pace-mapping is widely used to infer RPN's course, for limiting the risk of palsy by avoiding ablation at capture sites. However, information is lacking regarding the distance between the endocardial sites of capture and the actual anatomic RPN location. We aimed at determining the distance between endocardial sites of capture and anatomic CT location of the RPN, depending on the capture threshold. METHODS ANDRESULTS:
In consecutive patients undergoing AF radiofrequency ablation, we defined the course of the RPN on the electroanatomical map with high-output pacing at up to 50â mA/2â ms, and assessed RPN capture threshold (RPN-t). The true anatomic course of the RPN was delineated and segmented using CT scan, then merged with the electroanatomical map. The distance between pacing sites and the RPN was assessed. In 45 patients, 1033 pacing sites were analysed. Distances from pacing sites to RPN ranged from 7.5 ± 3.0â mm (min 1) when RPN-t was ≤10â mA to 19.2 ± 6.5â mm (min 9.4) in cases of non-capture at 50â mA. A distance to the phrenic nerve > 10â mm was predicted by RPN-t with a ROC curve area of 0.846 [0.821-0.870] (P < 0.001), with Se = 80.8% and Sp = 77.5% if RPN-t > 20â mA, Se = 68.0% and Sp = 91.6% if RPN-t > 30â mA, and Se = 42.4% and Sp = 97.6% if non-capture at 50â mA.CONCLUSION:
These data emphasize the utility of high-output pace-mapping of the RPN. Non-capture at 50â mA/2â ms demonstrated very high specificity for predicting a distance to the RPN > 10â mm, ensuring safe radiofrequency delivery.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Nervo Frênico
/
Fibrilação Atrial
/
Valor Preditivo dos Testes
/
Ablação por Cateter
/
Imageamento Tridimensional
/
Traumatismos dos Nervos Periféricos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article