Prognostic Value of a Laboratory Index of Frailty in Older Patients Hospitalized for COVID-19: The COMEPA Study.
J Frailty Aging
; 13(3): 213-217, 2024.
Article
em En
| MEDLINE
| ID: mdl-39082764
ABSTRACT
BACKGROUND:
Several indexes based on clinical and laboratory tests to identify frailty and to predict mortality have been produced. Only two studies, mixing clinical and laboratory parameters were made about a frailty index made of laboratory tests (FI-Lab) and mortality in older patients hospitalized for COVID-19. The aim of this study was to explore the accuracy and precision of an FI-Lab constructed with some common bio-humoral tests and mortality in a cohort of patients hospitalized for COVID-19.METHODS:
The FI-Lab was constructed using 40 different bio-humoral tests during the first four days of hospitalization, with a score from 0 to 1. The association between FI-Lab and mortality was assessed using a multivariate Cox's regression analysis, reported as hazard ratios (HRs) and 95% confidence intervals (CIs). The accuracy of the FI-Lab was reported as area under the curve (AUC) and the precision with the C-Index.RESULTS:
376 patients (mean age 65 years; 53.7% males) were initially included. During the follow-up period, 41 deceased. After adjusting for five different factors, an FI-Lab value >0.54, the median value of our cohort, was associated with a relative risk about five times greater than lower values. Modeling FI-LAB as a continous variable, each increase in 0.01 points was associated with an increased risk in mortality of 8.4% (HR=1.084; 95%CI 1.039-2.044). The FI-Lab was highly accurate (AUC=0.91; 95%CI 0.87-0.95) and precise (C-Index=0.81) in predicting death.CONCLUSIONS:
A simple index based on common laboratory tests can be used to predict mortality among older people hospitalized for COVID-19.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fragilidade
/
COVID-19
/
Hospitalização
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article