Your browser doesn't support javascript.
loading
Modular and Regioselective Synthesis of Benzo-Fused Five-Membered Rings Enabled by Co/Ti Synergism.
Ma, Xiao-Di; Ma, Fang-Yuan; Jiao, Miao-Miao; Li, Jun-Ting; Duan, Xin-Fang.
Afiliação
  • Ma XD; College of Chemistry, Beijing Normal University, Beijing 100875, China.
  • Ma FY; College of Chemistry, Beijing Normal University, Beijing 100875, China.
  • Jiao MM; College of Chemistry, Beijing Normal University, Beijing 100875, China.
  • Li JT; College of Chemistry, Beijing Normal University, Beijing 100875, China.
  • Duan XF; College of Chemistry, Beijing Normal University, Beijing 100875, China.
Org Lett ; 26(31): 6658-6663, 2024 Aug 09.
Article em En | MEDLINE | ID: mdl-39083395
ABSTRACT
The regiocontrol in constructing benzo-fused five-membered rings by C-H cyclization remains an important challenge. We report a highly general and regioselective methodology to access such heterocycles and indenones, where under the catalysis of CoBr2/bipyridine, aryl titanates, alkynes and EX2 (E = NR, S(O), RP(O), R2Si, CO, etc.) were assembled to various heterocycles and indenones in a modular manner. Unprecedented 1,2-Co/Ti heterobimetallic arylene and benzotitanole intermediates have played crucial roles in these syntheses.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article