Anti-Inflammatory Effect of Atorvastatin on Primary Human Endothelial Cells Incubated under Genotoxic Load.
Bull Exp Biol Med
; 177(2): 177-180, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-39090468
ABSTRACT
The level of cytokine expression was measured in human coronary artery (HCAEC) and internal thoracic artery (HITAEC) endothelial cells exposed to 500 ng/ml alkylating mutagen mitomycin C (MMC) and 5 µM atorvastatin. It was found that treatment of MMC-exposed HCAEC with atorvastatin decreased secretion of macrophage migration inhibitory factor (MIF), IL-8, and IL8 gene expression, but increased the expression of SERPINE1 gene encoding the PAI-1 protein. In atorvastatin-treated HITAEC, the concentration of MIF protein and the expression of the IL8 and SERPINE1 genes were reduced. We can conclude that atorvastatin prevents proinflammatory activation of endothelial cells cultured under conditions of genotoxic load. However, the molecular mechanisms of this effect require further research.
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Base de dados:
MEDLINE
Assunto principal:
Interleucina-8
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Mitomicina
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Inibidor 1 de Ativador de Plasminogênio
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Vasos Coronários
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Células Endoteliais
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Atorvastatina
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article