Unveiling potential: urinary exosomal mRNAs as non-invasive biomarkers for early prostate cancer diagnosis.
BMC Urol
; 24(1): 163, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-39090720
ABSTRACT
BACKGROUND:
This study investigated the use of urinary exosomal mRNA as a potential biomarker for the early detection of prostate cancer (PCa).METHODS:
Next-generation sequencing was utilized to analyze exosomal RNA from 10 individuals with confirmed PCa and 10 individuals without cancer. Subsequent validation through qRT-PCR in a larger sample of 43 PCa patients and 92 healthy controls revealed distinct mRNA signatures associated with PCa.RESULTS:
Notably, mRNAs for RAB5B, WWP1, HIST2H2BF, ZFY, MARK2, PASK, RBM10, and NRSN2 showed promise as diagnostic markers, with AUC values between 0.799 and 0.906 and significance p values. Combining RAB5B and WWP1 in an exoRNA diagnostic model outperformed traditional PSA tests, achieving an AUC of 0.923, 81.4% sensitivity, and 89.1% specificity.CONCLUSIONS:
These findings highlight the potential of urinary exosomal mRNA profiling, particularly focusing on RAB5B and WWP1, as a valuable strategy for improving the early detection of PCa.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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RNA Mensageiro
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Biomarcadores Tumorais
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Exossomos
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Detecção Precoce de Câncer
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article