An outbreak of severe or lethal infections by a multidrug-resistant Acinetobacter baumannii ST126 strain carrying a plasmid with blaNDM-1 and blaOXA-58 carbapenemases.
Diagn Microbiol Infect Dis
; 110(2): 116428, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39094238
ABSTRACT
Acinetobacter baumannii poses a significant health threat because of its frequent implications in hospital outbreaks and multidrug resistance (MDR). Here, we studied four A. baumannii isolates recovered during a hospital outbreak of severe or fatal cases to elucidate their diversity and factors contributing to their increased virulence and antibiotic resistance. The isolates were identified using MALDI-ToF and characterized using comparative genomics, PCR, and antimicrobial susceptibility tests. They were classified as ST126 and exhibited fewer than five chromosomal single-nucleotide variants and the same extrachromosomal content, indicating that they are a single strain (A. baumannii AB01). A. baumannii AB01 showed an MDR phenotype that could be linked to the carriage of parC and gyrA mutations, efflux transporters, aminoglycoside resistance genes, a class C beta-lactamase, and three carbapenemases, some of which are encoded on a 72 kb plasmid. ST126 is infrequent and has not been reported in Latin America, and our genomic data indicate a plausible origin for A. baumannii AB01 within the Pan Pacific region.
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MEDLINE
Assunto principal:
Plasmídeos
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Proteínas de Bactérias
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Beta-Lactamases
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Infecções por Acinetobacter
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Testes de Sensibilidade Microbiana
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Surtos de Doenças
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Farmacorresistência Bacteriana Múltipla
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Acinetobacter baumannii
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article